For the treatment of refractory schizophrenia,clozapine is suitable for refractory schizophrenia in which standard antipsychotic drugs do not work.

Because clozapine has the risk of inducing agranulocytosis and seizures,it is limited to patients taking standard antipsychotics after a certain course of treatment,because the effect is not obvious,or intolerable due to adverse reactions(see warning).

Because clozapine has the risk of inducing agranulocytosis and seizures,and it can occur throughout the treatment period,it is forbidden to extend the course of treatment to patients who have failed treatment.In addition,whether patients with clinical efficacy need to continue treatment should be re-evaluated regularly